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pentobarbital will enhance the stage or effect of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers lowered ivosidenib plasma concentrations.pentobarbital will lower the level or result of glecaprevir/pibrentasvir by affecting hepatic/inte